Lecture Title: Validation of Antibodies to Study the Human Proteome

Dr Uhlen received his PhD in chemistry at the Royal Institute of Technology (KTH), Stockholm, Sweden in 1984.  After a post-doc period at the EMBL in Heidelberg, Germany, he became professor in microbiology at KTH in 1988. His research is focused on protein science, antibody engineering and molecular medicine and has resulted in more than 550 publications with an h-index of 98 (Google Scholar).
The research range from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology.   Early in his career, he developed engineered protein A for purification of antibodies and methods based on his innovations is now used for manufacturing of a majority of therapeutic antibodies in the clinic today. He also pioneered the use of affinity tags, such as His-tags, for purification of fusion proteins and streptavidin solid phase techniques for DNA capture, two methods now widely used in life science. His group also described a new strategy for DNA analysis called Pyrosequencing, a method that was further developed to generate the first next generation sequencing instrument (454/Roche). A new affinity reagent called Affibodies was also developed and this has led to numerous papers and several molecules in clinical trials. Since 2003, he has led an international effort to systematically map the human proteome with antibodies and to create an open source knowledge-based resource called the Human Protein Atlas (www.proteinatlas.org).

Lecture Title: Application of protein microarrays in epigenetics and drug discovery

Dr. Heng Zhu is a Full Professor at Department of Pharmacology and Molecular Sciences at Johns Hopkins University School of medicine. He also holds appointments in the High-Throughput Biology Center and the Oncology Department at Hopkins. Dr. Zhu received his B.S. degree at Peking University, China and obtained his Ph.D. degree in Genetics (Dr. Ralph Dean) at Clemson University, South Carolina.  Dr. Zhu did his postdoctoral research in Dr. Michael Snyder's group at Yale University when he and his colleagues invented the proteome chip technology. In 2004, Dr. Zhu joined the faculty of the Johns Hopkins University School of Medicine. During the years, Dr. Zhu’s group has been focusing on the development and application of proteome microarrays to address both basic and clinical questions. His group has constructed the world-largest proteome microarray, comprised of ~20,000 individually purified human proteins in full-length. Using this powerful tool, his group has developed new approaches to construct signaling networks and pathways via identification of enzyme-substrate relationships and to profile DNA- and RNA-protein interactions. His group has also applied the human proteome microarrays to determine the underlining principle of pathogen-host interactions. In parallel, Dr. Zhu and colleagues applied the human proteome microarrays to discovery novel biomarkers in autoimmune diseases and cancer.

Lecture Title: Exploring the diversity in the human proteome

Lecture Title: More power and more depth: new tools for proteomics data processing

Dr. Lennart Martens is Professor of Systems Biology at Ghent University, and Group Leader of the Computational Omics and Systems Biology (CompOmics) group at VIB, both in Ghent, Belgium.
He has been working in proteomics bioinformatics since his Master’s degree, which focused on the computational interpretation of peptide mass spectra. He then worked as a software developer and framework architect for a software company for a few years, before returning to Ghent University to pursue a Ph.D. focused on proteomics and proteomics informatics. During this time, he worked on the development of high-throughput peptide centric proteomics techniques and on bioinformatics tools to support these new approaches.
In 2003, Dr. Martens started the PRIDE proteomics database at the EBI as a Marie Curie fellow of the European Commission. After obtaining his Ph.D. in Sciences: Biotechnology from Ghent University, he rejoined the PRIDE group at EBI, which he coordinated for several years before moving back to Ghent University to take up his current position.
Dr. Martens was Chair of the ABRF iPRG in 2011, is a Board Member of DELSA, of the Royal Flemish Society for Chemistry – Proteomics, and of the Belgian Proteomics Association (BePA), was elected to the Young Academy of the Royal Academy for Sciences and Arts in Belgium, and was elected to the HUPO Council in 2016. He was awarded the Prometheus Award for Research Excellence by Ghent University in 2014, and the Juan Pablo Albar ‘Proteomics Pioneer’ Award by EuPA in 2015. He serves as Academic Editor for PLoS ONE and Open Proteomics, and holds Editorial Board positions at PROTEOMICS, BBA Proteins and Proteomics, and Molecular BioSystems. An author on more than 170 peer-reviewed papers in the field, he has also co-written two popular Wiley textbooks: Computational Methods for Mass Spectrometry Proteomics, and Computational and Statistical Methods for Protein Quantification by Mass Spectrometry.

Lecture Title: More power and more depth: new tools for proteomics data processing

Peter Nilsson is a Professor in Proteomics at SciLifeLab, KTH - Royal Institute of Technology, in Stockholm, Sweden. He received his PhD degree in Biotechnology from KTH in 1998. Since 2003, he is the head of the Protein Microarray group within the Human Protein Atlas and the director of the Affinity Proteomics national platform at SciLifeLab since 2013. He is also the Vice Dean of KTH School of Biotechnology.  PN is a member of the steering group of HBPP since 2015 and organizer of the 25th HUPO Human Brain Proteome Project Workshop in Stockholm May 2016.
The research focus is based on the development and utilization of various antibody, protein, peptide and serum microarray technologies for protein and autoantibody profiling in body fluids and biomarker discovery applications, mainly within neuroscience and inflammation.

Lecture Title: Exploring the diversity in the human proteome

Richard D. Semba, M.D., M.P.H., is the W. Richard Green Professor of Ophthalmology at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Dr. Semba received his B.S. from Yale University, M.D. from Stanford University, and M.P.H. from Johns Hopkins University. He did residency training in ophthalmology at the Wilmer Eye Institute. Dr. Semba has authored or co-authored over 340 scientific articles, 32 reviews, and 35 book chapters. He is the author of Handbook of Nutrition and Ophthalmology (2007), The Vitamin A Story: Lifting the Shadow of Death (2012), and A Perfect Vision: Catalogue of the William Holland Wilmer Rare Book Collection (2013). He is co-editor of the widely-used textbook Nutrition and Health in Developing Countries (2008). Dr. Semba has diverse research interests. He uses proteomics and metabolomics to gain insight into age-related macular degeneration, aging-related phenotypes, and maternal and child health in developing countries.

Lecture Title: iMALDI for accurate quantitation of the expression and phosphorylation level of Akt in tumour biopsies

Dr. Borchers received his B.S., M.S. and Ph.D. from the University of Konstanz, Germany.  After his post-doctoral training and employment as a staff scientist at NIEHS/NIH/RTP, in North Carolina, he became the director of the UNC-Duke Proteomics Facility and held a faculty position at the UNC Medical School in Chapel Hill, NC (2001-2006).  Since then, Dr. Borchers has been employed at the University of Victoria (UVic), Canada and holds the current positions of Professor in the Department of Biochemistry and Microbiology and the Don and Eleanor Rix BC Leadership Chair in Biomedical and Environmental Proteomics.  He is also the Director of the UVic – Genome BC Proteomics Centre, which is a member of the Genome Canada funded Genomics Innovation Network. Dr. Borchers is also appointed as Professor at McGill University in the Department of Oncology, Montreal, QC and received there the Segal Chair in Molecular Oncology at the Jewish General Hospital of the McGill University.

Lecture Title: Verification of oral cancer biomarkers and their translation to clinical settings

Lecture Title: Genetically encoded protein photocrosslinker for comparative proteomics

Professor Peng Chen obtained his BS degree in Chemistry from Peking University in 2002 and Ph.D with Prof. Chuan He in Chemistry at The University of Chicago in 2007. After a postdoctoral training with Prof. Peter Schultz at The Scripps Research Institute between 2007 and 2009, he started his independent career as an Investigator in Chemical Biology at Peking University in July 2009 and has been promoted to Full Professor with tenure on Aug 2014. His Lab is interested in developing and applying novel chemistry tools to investigate protein-based interactions and activities in living cells. He has published 50 peer-reviewed papers on top scientific journals and magazines including Nature Chemistry, Nature Chemical Biology, and JACS and ACIE. He received NSFC Distinguished Young Scholar Award in 2012, China Young Scientists Award in 2013, RSC Chemical Society Review Emerging Investigator lectureship in 2014 and The Chemical Society of Japan Distinguished Lectureship Award in 2015. He is now the Chairman of Department of Chemical Biology at Peking University.

Lecture Title: Spatially-resolved proteomic mapping in living cells via enzyme-mediated proximity labeling

Alice Ting is a Professor of Genetics, Biology, and Chemistry at Stanford University. She received her undergraduate degree at Harvard University, working with E. J. Corey, and her Ph.D. from U. C. Berkeley, working with Peter Schultz. After her postdoctoral training with Roger Tsien, Alice started her laboratory at MIT in 2002, and in 2016, relocated as a full professor to Stanford University. Alice develops technologies for measuring and manipulating biomolecules and biochemical events in living cells. Her work has been recognized by awards from the McKnight Foundation, Dreyfus Foundation, American Chemical Society, Office of Naval Research, and Sloan Foundation. She has received the NIH Pioneer Award, the Arthur C. Cope Scholar Award, the Technology Review TR35 Award, and the Eli Lilly Award in Biological Chemistry.

Lecture Title: Chemical Proteomics Reveals the Target Landscape of >200 Clinical Kinase Inhibitor Drugs

Bernhard Kuster is a chemist by training and obtained is PhD in Biochemistry from the University of Oxford. He went on to do a PostDoc funded by an EMBO long-term fellowship at the EMBL in Heidelberg and the University of Southern Denmark in Odense. After seven years at the biotech firm Cellzome in Heidelberg as Vice President for Analytical Sciences and Informatics, he became Full Professor of Proteomics at the Technical University of Munich in 2007 where he is also the Chair of the Department for Biosciences and Co-Director of the Bavarian Biomolecular Mass Spectrometry Center. Bernhard’s research focuses on mass spectrometry based proteomics, big data informatics and their application to chemical and systems biology.

Lecture Title: Thermal Proteome Profiling for Drug Discovery

Mikhail Savitski studied physics and mathematics at Uppsala University graduating in 2003. He did his PhD in the lab of professor Roman Zubarev also at Uppsala University. After that he joined the company Cellzome in Heidelberg first as a scientist and then as group leader in the analytical sciences department. Since 2016 he is team leader and head of proteomics core facility at EMBL Heidelberg heading a research group and the proteomics core facility.

Lecture Title: Proteomic-scale approaches for identifying reversible and irreversible cysteine redox post-translational modifications in myocardial ischemia / reperfusion

Lecture Title: ROSics: Principle of ROS in oxidative modifications and structural regulations

Kong-Joo Lee completed her PhD from Stanford University and postdoctoral studies from Stanford University School of Medicine. She is a professor in College of Pharmacy, Ewha Womans University, Korea. She has published more than 100 papers on proteomic algorithm for identification of novel modifications (MODi) and disulfide linkage (DBonds), redoxomics, ROS signaling and regulation, cancer metastasis, post-translational modifications with MS, oxidative stress target molecules, structural changes by ROS and hydrogen-deuterium exchange mass spectrometry (HDX-MS) for analysis of structural change by protein modifications and chemical interactions in reputed journals. She has been serving as an editorial board member of Molecular Cellular Proteomics and is working as President of International Network Women Engineers and Scientists (INWES).

Lecture Title: Proteomic and metabolic health phenotypes in dietary clinical interventions

Loïc Dayon received his PhD in Bioanalytical Chemistry from the Ecole Polytechnique Fédérale de Lausanne (Switzerland) in 2006. He completed his education in the Biomedical Proteomics Group at the University of Geneva before being employed as a Senior Research Scientist at Proteome Sciences plc (London, UK). His activities within these groups covered the discovery of innovative brain disease markers, the development of mass spectrometry-based quantitative approaches for proteomics, and the separation of peptides with liquid chromatography and isoelectric focusing.

Lecture Title: Proteome homeostasis and remodeling in the stressed myocardium

Dr. Maggie Lam’s research focuses on deciphering the organizational principles of the cardiac proteome, by developing methods to analyze and model the spatiotemporal dynamics of protein networks. Her work routinely leverages a combination of analytical and computational approaches to understand cardiac and cellular physiology, with highlights including a series of multi-dimensional liquid chromatography platforms for deep proteome and glycome characterization, experimental workflows to quantify protein post-translational modifications in cardiac mitochondria, and an algorithm to annotate protein lists based on publications in the cardiovascular literature. She is currently a project scientist at the University of California at Los Angeles, where she is working to model the gradual reorganization of the cardiac proteome during cardiac hypertrophy and oxidative stress using the steady-state abundance and half-life of cardiac protein pathways.

Lecture Title: Targeting Epidermal Growth Factor Receptor (EGFR) in Lung Cancer: Towards Interactome-informed Medicine

Igor Stagljar is a Professor in the Departments of Biochemistry and Molecular Genetics at the Donnelly Centre in the University of Toronto, Canada. He received his Ph.D. in Molecular Biology from ETH Zurich in Switzerland. His postdoctoral fellowship was at the University of Zurich, where he studied RNA transcription and DNA repair. In addition, Igor was a visiting scientist at the University of Washington in Seattle with Stan Fields, the inventor of the yeast two-hybrid technology. Igor was Assistant Professor at the University of Zurich from 2002-2005, Associate Professor at the University of Toronto since 2005, and Professor since 2010. Amongst his most significant scientific achievements to date are the elucidation of functions of various membrane proteins involved in human health and disease. To that end, his lab is using high-throughput interactive proteomics, genetic, and biochemical tools to understand how cell signaling and membrane transport pathways control cell behavior in normal and disease cells.

Lecture Title: Decoding Ligand Receptor Interactions

Bernd Wollscheid is a Professor for Chemical and Systems Biology at the Swiss Federal Institute of Technology in Zürich, Switzerland and Head of the D-HEST BioMedical Proteomics Platform (BMPP). After studying chemistry in Freiburg and Boston he obtained his PhD in Molecular Immunology from the Max-Planck Institute for Immunobiology. His postdoctoral research took him to the Institute of Systems Biology in Seattle where he pioneered and applied chemoproteomic technologies towards the identification and quantification of proteins and their interaction partners. Now at the Institute of Molecular Systems Biology and the Department of Health Sciences and Technology at ETH Zürich the Wollscheid group is focusing on biomedical research bridging the gap in understanding the genotype to phenotype transition via detailed analysis of the proteotype.

Lecture Title: Deciphering the major histocompatibility complex immunopeptidome

Etienne was born in Canada. He did a Ph.D. in Systems Immunology at the University of Montreal where he worked on the analysis of the cellular immunopeptidome. In 2013, he received a Marie Curie Intra-European Fellowship to carry out research in the group of Ruedi Aebersold in Switzerland. In 2015, he initiated the Human Immuno-Peptidome Project (HIPP) as part of the Human Proteome Project. 

Lecture Title: Food and Nutrition Proteomics: focus on food allergies

Paola Roncada is graduate in Chemistry and Pharmaceutical Technologies in 1995, University of Milano and PhD in Biochemistry, at Faculty of Medicine of University of Sassari  in 2001. From 2002 is responsible of Proteomics research of Istituto Spallanzani. From 2010-2015 was in the Board of Italian Proteomics Association, and in 2015 was elected in the executive Committee of Human Proteome Organization. Her activities and expertise in the field of proteomics applied to microbes, milk, food and public health is recognize at national and international levels, with important national and international collaboration, She was MC for Italy of European Project COST Food and Agriculture FA 1002, Farm Animal Proteomics, and now she is MC for Italy of another European  Cost Action, Food and Agriculture FA 1402, Imparas, Improved Risk assessment for new food proteins. Furthermore, she is work unit for proteomics of an EU-FP7 project, Prolific, and WG leader of the ERA -NET ARimNET (2016-2019).
She is editor for EuPA open Proteomics journal, and Journal of Proteomics (Elsevier) She was chair of two international meeting, one Final Showcase Farm Animal Proteomics (November 2014, Milano) and Back to Future Proteomics, Milano, European Proteomics Association, June 2015. She is the chair of initiative Food and Nutrition Proteomics, inside Human Proteome Project, and co PI of Mit-cHPP.

Lecture Title: Extracellular Glycosylation: How to See the Forest Despite All the Trees

Lecture Title: Comprehensive Analysis of N-Linked Protein Glycosylation Using NGAG and Mass Spectrometry

Hui Zhang graduated from Beijing University with a BS and a MS degrees and from University of Pennsylvania with a Ph.D. degree. After working at New England Biolabs, Cell Signaling Technology, and the Institute for Systems Biology, she joined Johns Hopkins University in 2006 and established Mass Spectrometry Facility. Her research interests are centered on the structural and functional analyses of proteins and multiple protein modifications by glycosylation, phosphorylation, and acetylation. Recently, her laboratory has developed several novel glycoproteomic and glycomic technologies to study protein glycosylation and applied the technologies to study cell surface glycoproteins and glycoproteins secreted to body fluids. These technologies enable the identification and quantification of glycoproteins, glycosites, glycans associated with each glycosite and their occupancies.  Researchers in the group participate in several national programs in characterization of glycoproteins including the Early Detection Research Network (EDRN), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Programs of Excellence in Glycosciences (PEG)

Lecture Title: Molecular Imaging of the Brain by Mass Spectrometry

Dr. Per Andrén is Professor in Mass Spectrometry Imaging at the Dept. of Pharmaceutical Biosciences, Uppsala University, Sweden. He received his MSc in Pharmacy in 1984 and his PhD in 1989 in Medical Sciences (Psychiatry) also at Uppsala University. He did a postdoctoral fellowship and associate professorship at University of Texas Medical School, Houston, USA with Professor Richard M. Caprioli (1989-1995). He has also worked at GE Healthcare (R&D) as a Staff Scientist (2000-2009) and as a Guest Professor at Dept. of Biotechnology, Analytical Biotechnology, Delft University, the Netherlands (2008-2009).

Lecture Title: Peptide and Glycan Mass Spectrometry Imaging as Diagnostic Tool in Cancer Research

Prof Hoffmann received his PhD in Analytical Chemistry at University of the Saarland, Germany in 1999. He spent four years in Melbourne working with Prof Richard Simpson and Prof Bruce Kemp where he specialised in the use of free-flow electrophoresis in proteomics and the detection of protein phosphorylation by mass spectrometry. He moved back to Germany in 2003 and played an integral role in establishing a proteomics facility at the University Leipzig, Germany. In 2005, he was recruited back to Australia to establish a Proteomics Centre at the University of Adelaide. He holds now a Chair in Proteomics and is Director of the Adelaide Proteomics Centre at the University of Adelaide. His research is focused on biomarker discovery in cancer, detection of protein phosphorylation and Tissue Imaging Mass Spectrometry. The Adelaide Proteomics Centre houses the national facility for Tissue Imaging Mass Spectrometry for Australia. Prof Hoffmann is Deputy Director of Institute of Photonics and Advanced Sensing one of the five research institutes at the University of Adelaide. Prof Hoffmann is also an elected member of the HUPO Council.

Lecture Title: Proteomics in Viral Infectious Diseases: Global and Targeted Functional Insights into the Virus-Host Interface

Ileana Cristea is a Professor in the Department of Molecular Biology at Princeton University. Her laboratory focuses on characterizing mechanisms of cellular defense against viruses, as well as mechanisms used by viruses to manipulate these critical cellular processes. Towards these goals, she has promoted the integration of virology with proteomics and bioinformatics. She has developed methods for studying virus-host protein interactions in space and time during the progression of an infection, which have allowed her group to bridge developments in mass spectrometry to important findings in virology. For example, her laboratory has contributed to the emergence of the research field of nuclear DNA sensing in immune response, and has discovered sirtuins as broad-spectrum antiviral factors. Dr. Cristea chairs the Infectious Disease initiative of the Human Proteome World Organization, is on the Executive Board of US HUPO, and has acted on the Education Committee of the American Society for Mass Spectrometry. She is a head instructor of the Proteomics Course at Cold Spring Harbor Laboratory, Senior Editor for mSystems and Proteomics, and an Editorial Board member of Molecular & Cellular Proteomics and Journal of Neuroimmune Pharmacology. She is the recipient of the Bordoli Prize from the British Mass Spectrometry Society (2001), NIDA Avant-Garde Director Pioneer Award for HIV/AIDS Research (2008), Human Frontiers Science Program Young Investigator Award (2009), Early Career Award in Mass Spectrometry from the American Chemical Society (2011), the American Society for Mass Spectrometry Research Award (2012), the Molecular Cellular Proteomics Lectureship (2013), and the Mallinckrodt Scholar Award (2015).

Lecture Title: Immunotherapy of Cancer; An Overview and Recent Results

Professor Donald F. Hunt joined the faculty at the University of Virginia as an assistant professor in September, 1968 and currently holds the rank of University Professor with appointments in both Chemistry and Pathology. He is the recipient of numerous awards including: Virginia's Outstanding Scientist, the Pehr Edman Award, the Distinguished Contribution Award from the American Society for Mass Spectrometry, the Christian B. Anfinsen Award from the Protein Society, the Chemical Instrumentation Award and the Frank F. Field and Joe L. Franklin Award from the American Chemical Society, the Thomson Medal from the International Mass Spectrometry Society, Distinguished Accomplishment Awards from the Human Proteome Organization (HUPO) and ABRF, the Distinguished Scientist Award at the University of Virginia, and the School of Medicine Dean’s Award for Excellence in Team Science.   He is a co-inventor on more than 30 patents and patent applications and has more than 390 scholarly publications to his credit.  His Google Scholar h-index of 106, (106 papers with 106 or more citations, total citations = 41,471, i10-index = 346) ranks him among the top 130 living chemists in the world. An RG score of 49.67 on Research gate places him in the top 97.5% of all members ot this scientific community.) Professor Hunt is a consultant to ThermoFisher Scientific Corp.

Lecture Title: Comprehensive DIA with high precursor selectivity: How can we have our cake and eat it too?

ecture Title: Comprehensive Analysis of Human Proteomes with similar depth as RNA-Seq

Jesper V. Olsen is a Danish scientist trained as an analytical chemist in the Group of Professor Roman Zubarev during his under-graduate studies at the University of Southern Denmark. He received his PhD in Molecular Biology from Matthias Mann’s laboratory at University of Southern Denmark in 2006. After post-doctoral work at the Max Planck Institute for Biochemistry in Munich, he joined the newly established Novo Nordisk Foundation Center for Protein Research at University of Copenhagen in 2009 as independent group leader and vice director since 2012. He has developed technologies for detection of proteins and their post-translational modifications (PTMs) with unprecedented throughput and quantitative precision and applied them to address unsolved questions in cell signaling. He has made seminal work in quantitative phosphoproteomics and succeeded in obtaining global maps of dynamic phosphorylation events in mammalian cells in a time-resolved manner as function of growth factor stimulus (EGF, FGF and NGF) or drug treatment (cell-cycle and DNA damage response). Jesper is since 2014 full professor at the University of Copenhagen, where his research interests continues to be in mass spectrometry-based proteomics with a specific focus on developing innovative technologies for deep proteome and PTM analyses, and apply these methods to study disease signaling networks in cell and tissue-based models. Jesper has received a number of research awards including the HUPO Young Investigator Award in Proteomic Sciences at the HUPO World Congress in 2008.

Lecture Title: Accurate mass- and glycan composition-based assignment of glycosylation site-specific glycomes of complex glycoprotein mixture

Dr. Hiroyuki Kaji is now a Group Leader of Glycoscience and Glycotechnology Research Group in Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science & Technology (AIST). He graduated from Aoyama Gakuin University and received Dr. of Science degree in 1989. He started proteomics study in 1997 at Tokyo Metropolitan University under Professor Toshiaki Isobe. Dr. Kaji moved to AIST in 2007 and has been worked with Dr. Hisashi Narimatsu in a field of glycoproteomics. His current interest is a development of methodology and its application on glycoproteomics. He serves as a Council member of JHUPO (2015-2016).

Lecture Title: Advances in Glycoproteomics Facilitate the Discovery of a New Class of Functionally Important Cancer and Inflammation-Centric Human Glycoproteins

Dr. Morten Thaysen-Andersen (MTA) is a Fellow of the Cancer Institute NSW at Macquarie University, Sydney, Australia. He obtained his PhD in Carbohydrate and Protein Chemistry in 2009 from University of Southern Denmark under the guidance of Prof. Peter Højrup, and completed two postdoctoral fellowships in Glycobiology at Macquarie University, Sydney, Australia under Prof. Nicki Packer awarded to him by the Danish and Australian Research Agencies. MTA now leads a research group at Macquarie University, Sydney, Australia that conducts research in Structural and Analytical Glycobiology with a focus on understanding how complex carbohydrates (glycans) affect the function of key proteins in complex biological systems including inflammation (innate immunity), cancer, and pathogenic-host interactions. His group develops and utilises state-of-the-art mass spectrometry-based technologies for the large-scale and accurate molecular mapping of carbohydrate-protein structures (glycomics and glycoproteomics) and uses complementary molecular and cellular assays to investigate the structure/function relationships of carbohydrate-conjugated proteins in the context of a range of human diseases.

Lecture Title: Multilayer Proteomics Approaches to Understanding Common Human Diseases

Dr. Junmin Peng is a Member/Professor at St. Jude Children’s Research Hospital and the Director of St. Jude Proteomics Facility. He attended Wuhan University and received a bachelor degree in biochemistry in 1991 and three years of graduate training in genetics, before he moved to the University of Iowa, where he cloned the transcription elongation factor P-TEFb (CDK9/Cyclin T) under the guidance of Dr. David Price and obtained his Ph.D. in biochemistry. Then he journeyed to Harvard Medical School for postdoctoral training in Neuroscience mentored by Dr. Li-Huei Tsai, as well as in Mass Spectrometry/Proteomics in the laboratory of Dr. Steven Gygi. He joined Emory University as a faculty member in 2002 and has worked in St. Jude Children’s Research Hospital since 2011. Dr. Peng has been interested in developing high-throughput mass spectrometry-based proteomics and metabolomics technologies, systems biology approaches, and the application to biomedical challenges (e.g. ubiquitin biology, Alzheimer’s disease and cancer). Beyond big data analysis, his lab also performs a series of functional experiments to validate the derived hypotheses. He contributes to the development of the target-decoy strategy for protein identification, the mapping of ubiquitinated proteome and synaptic proteome, as well as the discovery of unconventional polyubiquitin chains and RNA splicing dysfunction in Alzheimer’s disease. Dr. Peng has published 140+ scientific papers (total citations of 15,300+, http://scholar.google.com/citations?user=vFzS-awAAAAJ&hl=en) and has been invited to present his work in 60+ conferences, academic institutes and companies. In addition, he has trained 35+ graduate students, postdocs and staff scientists.

Lecture Title: Membrane protein complexes

Dr. Jun Qin is among the few people in the world, who can integrate MS instrument design, proteomic method development, bioinformatics, biology and clinical applications into one research program. He made multiple contributions to the field of DNA damage response and nuclear hormone action by isolation and identification of endogenous protein complexes, identification of in vivo post-translational modifications and elucidation of their functional significance. As an important part of our research, he is continuously developing novel MS-based proteomic methods to analyze dynamic changes of complex biological processes in a quantitative manner. He has a long standing interest on a concept of "network analysis proteomics." Proteins tend to assemble into multi-subunit protein complexes as the minimal biologically functional units. The execution of biological processes in the cell can be viewed as a network of ordered interactions between different protein complexes, benefits the understanding of the basic mechanisms of cellular homeostasis and pathogenesis. Specifically, he analyzed the endogenous protein complexome by immunoprecipitation (IP) with primary antibody and mass spectrometry and constructed a complete human protein interactome. He is interested in understanding several intriguing biological processes, with a special emphasis on the development and application of cutting-edge mass spectrometry-based proteomics toolkits to untangle challenging biological problems.

Lecture Title: Affinity Proteomics with Plasma Biobanks - From Discovery to Validation

Jochen M. Schwenk is Associate Professor for Translational Proteomics at KTH - Royal Institute of Technology in Stockholm, Sweden. He is Director of the Biobank Profiling facility at the Science for Life Laboratory and a Principal Investigator within the Human Protein Atlas and the KTH Center for Applied Proteomics. His research focuses on advancing and applying affinity proteomics methods for multiplexed plasma analysis of large sample sets from population and disease biobanks. His interests are finding protein-disease associations, validating antibodies and confirming indicative target proteins in clinical samples.  With the aim to translate discoveries into applications, his team is working on the integration of novel affinity-based methods, mass spectrometry, study experimental designs, data processing and statistical analyses. His lab is currently involved in a variety of plasma biomarker projects, including studies of health or diseases such as cancer, diabetes and cardiovascular disorders. Jochen received his PhD in Biochemistry from the University of Tübingen, Germany for his work at the Natural and Medical Sciences Institute (NMI) on protein-based microarrays. He then joined the Human Protein Atlas for his postdoctoral work, where he developed multiplexed immunoassays for protein and antibody profiling of body fluids.

Lecture Title: Social implementation vision of All-in-One Urine Test for Health Check

I graduated from Niigata University School of Medicine in 1974 and took an internship course for one year. Then, I started a research on kidney disease in the Institute of Nephrology, Niigata University. I have studied pathology, cell biology, molecular biology and proteomics.
I played a role in establishment of the HUPO Kidney and Urine Initiative (HKUPP) in 2007 to study kidney functions and diseases by proteomics. This project has provided 1) Human Kidney and Urine Proteome Databases in collaboration with HUPO Human Antibody Initiative and 2) Standard Guideline for Urine Proteomics through the HKUPP website (http://www.hkupp.org/). I have been serving as a HUPO council since 2011 and I was elected as the President of Japan Proteomics Society (JProS) in 2012-2014 and have been chairing the Chromosome X project in the chromosome-based Human Proteome Project (c-HPP).  My current interests in research are proteomic analysis of the kidney for understanding pathophysiology of kidney diseases and discovery of urine biomarkers for prediction of not only kidney diseases but also any other diseases as “All-in-One” urine test project. The project started in 2013 as a Center of Innovation (COI) program supported by Japanese government for nine years.

Lecture Title: Unraveling mechanisms of liver disease progression by shotgun and targeted proteomic approaches.

Fernando J Corrales received the BSc degree in Biological Sciences (1986) and the phD degree in Biochemistry and Molecular Biology (1992) from the University Autónoma of Madrid. After a Postdoctoral period at the University of Cambridge (UK), he started at the University of Navarra where he is currently Professor of Biochemistry and Molecular Biology, Senior Scientist and Director of the Proteomics, Genomics and Bioinformatics Facility of the Centre for Applied Medical Research. He is an active researcher in the field of Biochemistry. His interest is now focused on the study of the mechanisms associated to liver function as well as those involved in the progression of liver diseases using proteomics and genomics approaches, which are then combined in a systems biology-based strategy. His research activity has been regularly founded by regional, national and international grants and lead to the publication of more than 110 scientific articles. He is member of the editorial board of different journals specialized in proteomics and hepatology, General Coordinator of the Molecular and Bioinformatics resources Platform and ProteoRed (Spanish Proteomics Network) and is member of the Executive Councils of the European Proteomics Association and the BD and C-Human Proteome Project.

Lecture Title: Drug-Drug Interaction – Analyses of CYP450 Enzymes and Transporters in Mice and Men

Dr. Oliver Poetz (Germany, 1974) has been working with the Natural and Medical Sciences Institute at the University of Tuebingen since 2002. Since 2010 he heads the department of protein analytics.
The Group of Dr. Poetz is developing a generic strategy for immunoaffinity-based proteomics. Immunoaffinity enrichment of proteotypic peptides coupled with mass spectrometry is a highly specific and sensitive approach for determining the absolute concentration of proteins from complex mixtures. However, the 'one antibody - one analyte' approach requires a high number of specifically generated binding reagents, thereby limiting the use of this concept for a proteome-wide scale. He addresses this problem by generating antibodies that recognize short c-terminal epitopes. These antibodies are thus capable of simultaneously enriching multiple peptides. This 'one antibody - multiple analyte' strategy substantially reduces the number of antibodies required for a proteome scale, while high sensitivity can still be obtained.
He was given the GO-Bio award for a research project in which he uses this strategy to develop and commercialize immunoassays capable of detecting toxicologically relevant biomarkers across species. His research focusses on drug-drug interaction studies, molecular responses of cells and tissues to xenobiotics, and safety biomarker validation.
Dr. Poetz studied biochemistry at the University of Tübingen, did his postdoctoral research at Institute of Toxicology, Tuebingen, Germany before joining the Natural and Medical Sciences Institute. 2010 he joined the UVIC-Genome BC Proteomics Centre (Vancouver island, BC Prof. Christoph Borchers) on a sabbatical. Dr. Poetz is Member of the Human Proteome Organization HUPO, the American Society for Mass Spectrometry (ASMS), the American Society for Biochemistry and Molecular Biology (ASBMB) and the German Society for Biochemistry and Molecular Biology (GBM). Since 2014 he is the chair of the GBM working group Bioanalytics.

Lecture Title:

Frank Gonzalez is Chief, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland USA. He received a Ph.D. in Oncology from the University of Wisconsin, Madison and did postdoctoral studies at the National Institute of Child Health and Human Development, National Institutes of Health before joining the National Cancer Institute. His group studies drug and carcinogen metabolism, and mechanisms of chemical carcinogenesis, primarily using mouse models.  They employ LC/MS-based metabolomics to discover biomarkers for early cancer diagnosis and for the monitoring of cancer therapy and recurrence. The Laboratory of Metabolism also studies metabolic diseases such as obesity, insulin resistance and fatty liver disease, all of which are risk factors for cancer, and increase mortality in cancer patients. Recent studies have uncovered a novel pathway by which the gut microbiota influence obesity, insulin resistance and NAFLD, that has led to novel insights into potential clinical intervention into these disorders.

Lecture Title: Single Cell Metabolomics and Applications

Tsutomu Masujima, Ph.D. is now the Team Leader of Single-cell Mass Spectrometry Laboratory in Quantitative Biology Center of RIKEN and also the Professor Emeritus of Hiroshima University where he was graduated, and worked finally as the professor of Analytical Chemistry Lab. in Pharmaceutical Sciences from 1989-2014.  He innovated original and unique single cell analysis method called “Live Single-cell Mass Spectrometry” in 2007 in which the cell contents are sucked by a glass needle of nano-spray tip under the observation of the cell with a video-microscope and the contents are directly fed to the mass spectrometry within a few minutes after addition of ionization solvent from rear end of the tip.
Since this unique live single cell analysis method is simple, rapid, direct, ultra-sensitive and comprehensive with thousands of molecular peaks of small molecules, many applications have been performed from basic life science to clinical medicine. The studies are mainly in metabolomics and now opening the lipido-metabolomics and then aimed to proteomics in near future.

Lecture Title: Employing neuroproteomics to understand the molecular basis of schizophrenia

After having spent 6 years in postdoctoral training in Germany (Max Planck Institute of Psychiatry and Ludwig Maximilians University of Munich) and in the UK (University of Cambridge), Dr. Martins-de-Souza has become in 2014 Assistent Professor and Head of Proteomics in the Dept of Biochemistry of the University of Campinas (UNICAMP), in Brazil. There he started the Laboratory of Neuroproteomics (LNP), funded by FAPESP's Young Investigator program (http://www.bv.fapesp.br/3850). The LNP aims to unravel the molecular mechanisms and biomarkers candidates associated to psychiatric disorders using state-of-the-art proteomic techniques.

Lecture Title: Exploring the role of hydrogen sulfide in neurodegenerative disorders

Prof. Andrea Urbani started his research experience in 1990 within the Protein Biochemistry group of Prof. Federici (Tor Vergata University, Rome). During the PhD training (1994-1998) he has been working in the Merck, Sharp and Dohme laboratories of Pomezia (IRBM P. Angelini, Rome) on the functional and structural characterisation of the NS3 serine protease from the Hepatitis C Virus. This activity has led to the filing and extension of two patents application by MSD. Upon gaining the PhD title he moved to Heidelberg (Germany) at the European Molecular Biology Laboratory (EMBL) in the Structural Biology Programme (1998-2001) where he has pursued structural and functional investigation on integral membrane protein complexes. Following this experience I moved as a visiting scientist at the German Cancer Research Centre (Deutsches Krebsforschungszentrum) in the Analitycal Protein Chemistry unit where he has dedicated most of the investigations in the proteomics area. In his scientific experience he has been involved in protein characterisation by a number of different techniques. Mass spectrometry characterisation and identification of proteins represent the light motif of the laboratory he has developed during the last ten years.
He is currently the President of the Italian Proteomics Association (ItPA) and President of the European Proteomics Association (EuPA) for the years 2015-2017. His international publication record is represented by over 170 contributions on journal with peer review system for a total impact factor above 600, his h-index is 32 based on approx. 3408 citations (SCOPUS, Elsevier, February 2016).

Lecture Title: Proteomics 2.0: Recent Advances in Top Down Proteomics

Dr. Kelleher’s laboratory has three main sub-groups working in the areas of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Cancer Epigenetics.  The Kelleher group has been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology.  Since 2011, Dr. Kelleher has served as the director of the Proteomics Center of Excellence at Northwestern University, where >100 laboratories are supported and beyond state-of-the-art in Top Down proteomics is developed.  Dr. Kelleher was elected Treasurer of the American Society for Mass Spectrometry in 2012 and co-founded the Consortium for Top Down Proteomics that same year (); the Consortium hosts a database of known proteoforms visible here:  http://repository.topdownproteomics.org/ .  In September 2012, Dr. Kelleher gave a keynote address at World HUPO (Boston), where he described a “Top Down” version of the Human Proteome Project viewable at this URL (http://www.kelleher.northwestern.edu/human-proteome-project/the-talk).  With more than 300 papers published over the course of his career and teaching duties in two departments, Dr. Kelleher is a trans-disciplinary investigator with visible streaks of international impact in mass spectrometry-based proteomics and the discovery of new natural products from the microbial world.  Validation of protein-based biomarkers in organ transplantation and cancers of the blood are among the focused areas currently being pursued in clinical research at Northwestern in Chicago, USA.

Lecture Title: Capturing the dynamic spatial proteome

Kathryn S. Lilley – Research Group Head and Director, Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, UK.
Kathryn received her PhD in Biochemistry from the University of Sheffield in 1990. She continued her scientific career as a laboratory manager for 11 years at the University of Leicester where she ran the Protein and Nucleic Acid Laboratory core facility. In November 2000, she established the Cambridge Center for Proteomics (CCP) of which she is director which sits within the Cambridge Systems Biology Centre, University of Cambridge. This state-of-the-art center collaborates with a large number of groups in the UK and worldwide.
In parallel to this, she established a research programme and her laboratory is now at the forefront of technology development which enables measurement of the dynamics of the proteome in a high throughput manner in space and time during critical cellular processes such as signaling and differentiation. Her group has also contributed many open-source informatics tools necessary to efficiently mine and visualise the extremely complex data which is produced by spatiotemporal proteomics studies. Kathryn was appointed to a personal Readership in 2008 and Professorship in Cellular Dynamics in 2012. She was elected as a Fellow of Jesus College Cambridge in 2010. More recently she has been awarded a prestigious Wellcome Trust Joint Investigator Award in January 2016 with Professor Anne Willis of the MRC Toxicology Unit, Leicester, and her future research will also investigate the implication of where transcripts are translated upon the spatial proteome and how this process is controlled.

Lecture Title: Quantitative Proteomics to Support the Discovery and Development of Targeted Drugs

Henrik Daub received his PhD from the Max Planck Institute for Biochemistry in Martinsried near Munich, for the discovery of fundamental signal transduction mechanisms in cell proliferation. After his postdoctoral studies in RhoGTPase signaling Henrik joined a Munich-based biotech company where he and his team pioneered the development of chemical proteomics methods. Subsequently, as a group leader at Max Planck Institute for Biochemistry, his research focus shifted towards quantitative phosphoproteomics and chemical biology applications. Henrik received his venia legendi for biochemistry from the Technical University of Munich. He was a founder of Kinaxo, a Max Planck spin-off company specializing on high-end proteomics services. Henrik joined Kinaxo as Chief Technology Officer in 2010, which was acquired by Evotec in the following year. He now serves as Senior Vice President Science & Technology at Evotec Munich, overseeing the development and application of proteomics technologies for drug and biomarker research.

Lecture Title: Kinase-centric pharmacoproteomics for molecular-targeting drug discovery

Professor Yasushi Ishihama has been working in the field of proteomics since 2001. He has made a significant contribution to this field especially by developing the basic technologies such as nanoLC-ESI columns, StageTip mini SPE columns (>1050 citations), label-free quantitation method named emPAI (>1240 citations), HAMMOC phosphopeptide enrichment, MS-compatible surfactants and so on. In addition, these tools/approaches have been immediately applied to biology such as a first Malaria proteome study (Nature 2002), a first plant tyrosine phosphoproteome study (Mol Syst Biol 2008), a first large-scale study on phosphorylation stoichiometry in human cells (Nat Commun 2015) and a comprehensive study on bacterial phosphoproteomics (Sci Sig 2015). Recently his group established so-called ‘one-shot’ proteomics by ultrahigh resolution monolithic silica columns to uncover proteome on a microarray scale, which will open the next generation proteomics. He is also interested in comprehensive analysis of kinase-mediated cellular phosphorylation network using experimental and computational approaches. 

Lecture Title: Application of mass spectrometric technology for quantifying changes in plasma membrane receptor-mediated signaling in Arabidopsis thaliana.

Professor Sussman is recognized as a leading expert in biological and genomic research. His research interests have focused on using the model higher plant, Arabidopsis thaliana, for understanding the role of plasma membrane proteins in signal transduction and solute transport. To help decipher the in situ role played by these proteins, his laboratory pioneered the development of genome-­‐wide reverse genetics techniques to isolate‘knockout’ plants (1). For example, his lab was the first to demonstrate that the plant homologue for a brain potassium channel is performing a nutritional role in higher plants (2).  More recently he has helped develop mass spectrometric approaches for identifying key proteins involved in signaling, including a receptor kinase that regulates cell elongation (3). In addition to these biological studies, his laboratory develops and utilizes new genomic technologies, including the invention of the maskless DNA array synthesizer, which was commercialized by a company he founded, NimbleGen Systems, Inc.  His current interests continue to focus on plasma membrane function and genomics, and includes the recent assembly and analysis of the genome sequence for the strong voltage South American electric eel, Electrophorus electricus. The goal of this was to determine the molecular underpinning by which nature has created a cell with a plasma membrane that can generate enough electric power to kill its prey and enemies (4).  Sussman's research has been funded by NSF, NIH, DOE and USDA and he has served on many federal advisory panels and editorial boards. His research has been recognized by many awards and honors, including election as a fellow in the American Association for the Advancement of Science and at UW-­‐Madison, with a chaired professorship provided by funds from the Alumni Class of 1933.
1.  Krysan, P.J., Young, J.C., Tax, F. and Sussman, M.R.  1996.  Identification of transferred DNA insertions within
Arabidopsis genes involved in signal transduction and ion transport.  Proc. Natl. Acad. Sci. 93:8145-­‐8150
2.  Hirsch, R.E., Lewis, B.D., Spalding, E.S., and Sussman, M.R. 1998. A role for the AKT1 potassium channel in plant
nutrition. Science 280:918-­‐ 921.
3. Haruta M, Sabat, G., Stecker, K., Minkoff, B.B. and Sussman, M. R. 2014 A Peptide Hormone And Its Receptor Protein Kinase Regulate Cell Expansion in Arabidopsis thaliana. Science 343:408-­‐411
4. Gallant JR, Traeger LL, Volkening JD, Moffett H, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon HH, Samanta MP and Sussman MR. 2014 Genomic basis for the convergent evolution of electric organs. Science. 344:1522-­‐5.

Lecture Title: Using proteomic tools to reveal new facets of plant signaling

W. Andy Tao received his mass spectrometry training through his dissertation work on gas-phase chiral analysis in the Aston Lab at Purdue University, headed by Dr. R. Graham Cooks. After receiving his Ph.D. in December 2001, he worked for three years as a Damon Runyon Postdoctoral Fellow in the Institute for Systems Biology at Seattle, under the supervision of Drs. Leroy Hood and Ruedi Aebersold. He started his own research group in the Department of Biochemistry at Purdue University in 2005, and currently is Full Professor in ranking. He also has courtesy appointments in the Department of Chemistry, Department of Medicinal Chemistry & Molecular Pharmacology, and Purdue Center for Cancer Research. Tao leads an active research group focusing on new developments in mass spectrometry-based proteomics. In particular, the Tao group has introduced multi-functionalized soluble nanopolymers as a platform for the study of molecular signaling and for the identification of intracellular drug targets. Current applications include the identification of direct kinase substrates and multiplex assay of protein phosphorylation in cancer cells and plants. Tao has co-authored over 100 research articles, invited reviews, and book chapters. He received NSF Career Award in 2007 and was the recipient for the 2006 ASMS research award.

Lecture Title: Enabling Data Sharing and Reuse: Recent progress and new projects for the HUPO Proteomics Standards Initiative

Dr. Eric Deutsch is a senior research scientist at the Institute for Systems Biology, specializing in bioinformatics and integration of data for systems biology research, with a focus on proteomics. He is the lead designer for the Systems Biology Experiment Analysis Management System (SBEAMS). He contributes to the development of minimum information standards and data formats as chair of the HUPO Proteomics Standards Initiative. Dr. Deutsch is the head of the PeptideAtlas Project, which aims to collect proteomic mass spectrometry data from labs around the world to synthesize a master list of observed peptides and proteins and disseminate the results back to the community. He also leads the team that develops the Trans-Proteomic Pipeline (TPP), the mostly widely used free and open source suite of tools for the complete analysis of shotgun proteomics data.

Lecture Title: The Golgi Localized UDP-GlcNAc transporter is required for the Maturation of Complex N-glycans in Plants

A/Prof Heazlewood received his PhD from the Botany Department at La Trobe University in 2001. He then took a postdoctoral position at the University of Western Australia examining mitochondrial function in plants using proteomic techniques. In 2005 he received an Australian Postdoctoral Fellowship to extend his research around the characterization of plant mitochondria and respiratory chain complexes. He spent 2007 at the Max Planck Institute of Molecular Plant Physiology (MPIMP) in Potsdam-Golm (Germany) as an Alexander von Humboldt Research Fellow using advanced mass spectrometry techniques to examine protein phosphorylation. Towards the end of 2007, he was invited to create a research team at the newly funded US Department of Energy, Joint BioEnergy Institute (JBEI) in Berkeley, California (USA). While at JBEI (2008 to 2014) he led the Plant Systems Biology research group which developed a program focused on the utilization of proteomics, imaging and bioinformatics on aspects of plant cell wall biosynthesis. In 2013, he was awarded an Australian Future Fellowship within the School of BioSciences at The University of Melbourne. The research objectives of the Future Fellowship are to relocate technologies and approaches developed at JBEI, principally focussing on plant cell wall biosynthesis. This includes endomembrane separation technologies, computational approaches to investigate post translational modifications, a systems analysis of nucleotide sugar metabolism and the characterization of plant nucleotide sugar transporters.

Lecture Title: A proteogenomic analysis of early onset gastric cancer

During Ph.D. study at MIT, he developed bioinformatic tools for integrative analyses of gene expression and metabolomic data. In 2003, he started his postdoctoral career at ISB and developed a data integration tool, Pointillist; proteomic data analysis tools, MS-BID and Prequips; a systems approach to prion disease; and a prion disease database. In 2006, he joined POSTECH in Korea and had developed systems approaches for understanding complex human diseases and proteomic approaches for identifying protein tissue/serum biomarkers for complex human diseases. In 2010, he became the director of System Biodynamics-National Core Research Center (NCRC). He developed tools for understanding spatiotemporal operations of biological networks. In 2013, he moved to DGIST in Korea and have been working on proteogenomic analyses of early onset gastric cancers and lung adenocarcinoma and network analysis of complex biological systems.

Lecture Title:

Lecture Title: Ubiquitin Proteomics – Revelations of a master manipulator

Dr. Donald S. Kirkpatrick is a Senior Scientist and group leader in Discovery Proteomics at Genentech. His team functions as part of the Protein Sciences Division where they utilize mass spectrometry to characterize cellular proteins and post-translational modifications. His group has a long standing interest in protein ubiquitination, and how dysfunction within this system contributes to the development of human disease. The work in his lab seeks to define and validate new therapeutic targets that lead to treatments for cancer and neurodegeneration.

Don received his B.S. in Biochemistry from University of Oklahoma and a Ph.D. in Pharmacology & Toxicology from the University of Arizona. Working in the lab of Prof. A. Jay Gandolfi, his thesis focused on dissecting the toxic mechanisms of low-level arsenic exposure and spawned a longstanding interest in Ubiquitin Biology and Mass Spectrometry Proteomics. In 2003, Don joined Prof. Steven Gygi’s lab at Harvard Medical School to perform post-doctoral research at the intersection of these two fields; using mass spectrometry to characterize site specific ubiquitination and the composition of ubiquitin signals on protein substrates. Don is currently on the Editorial Board of Molecular and Cellular Proteomics.

Lecture Title: Positional Proteomics Technologies to Functionally Annotate Tissue Proteomes in Pathology

Dr. Overall is a Professor and Tier 1 Canada Research Chair in Protease Proteomics and Systems Biology at the University of British Columbia, Centre for Blood Research. He completed his Honors Science and Masters at the University of Adelaide, South Australia; his Ph.D. at the University of Toronto; and MRC Centennial Fellow with Dr. Michael Smith, Nobel Laureate, UBC. He was a Visiting Senior Scientist at British Biotech Pharmaceuticals, Oxford (1997/1998) and Visiting Senior Scientist Novartis, Basel (2004/2008), External Senior Fellow, Freiburg Institute for Advanced Studies, and in 2014 was appointed as Honorary Professor, Albert-Ludwigs Universität Freiburg. Awarded the 2002 CIHR Scientist of the Year, the UBC Killam Senior Researcher Award 2005, and was the Chair of the 2003 Matrix Metalloproteinase and the 2010 Protease Gordon Research Conferences. Elected to HUPO Council and as Co-Chair of the Chromosome–Centric Human Proteome Project (C-HPP) in 2014. With over 15,571 citations for his 229 papers (since 2000 cited >11,454 times, 12 >300 citations), h index of 65 he is a highly influential scientist. Professor Overall is also the pioneer of degradomics, a term he coined. With 21 Nature Review, Nature Journal, Cell Journal, Science and Science Signaling papers he was recognized by the International Society of Proteolysis (2011 Lifetime Achievement Award); by the Matrix Biology Society of Australia and New Zealand (2012 Barry Preston Award); by the IADR Distinguished Scientist Award for Research in Oral Biology (2013); and in 2014 by the Tony Pawson Canadian National Proteomics Network Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community. He is an Associate Editor of the Journal of Proteome Research, Editor of mSystems.

Lecture Title: Precision analysis of proteome by HPLC-ESI-MS

Dr. PengyuanYang, a Fudan-Schollarship Professor, gained Ph D from the University of Massachusetts at Amherst. He currently is the Deputy Director of Institutes of BioMedical Sciences, Fudan University.
Dr. Pengyuan Yang is very active in bio-mass spectrometry for protein analysis, glycoproteomics and disease proteome areas. Dr. Pengyuan Yang is specialized in Mass-Spectrometry based technology and methodology, especially in the field of Biomass Spectrometry and its application in Glycoproteome and Cancer-proteome. He was the Principal Scientist for National 973 Project “Proteomics for disease study”(2002-2006), and for“Micro-fluidics and its application in chemistry and bio-medicine” (2007-2011), and is the Principal Scientist for National 863 Project “Instrumentation and reagent for proteomics”, supported by Ministry of Science and Technology. He is the Council Member of Chinese Mass Spectrometry Society. He is also a member of editorial board of Proteomics, and J Proteome Res. Dr. Yang has published a number of scientific papers on many important journals, including Anal Chem, Ripad Commun Mass Spectr, Proteomics, J Res Proteome, Mol Cell Proteomics, Adv Mater, Angrew Chem Int Ed., Chem Comm.

Lecture Title: Big Data infrastructure for Chinese Human Proteome Project

Prof. Weimin Zhu was originally trained as a biomedical engineer in his undergraduate years. He pursuit more in-depth trainings in both molecular biology and data informatics in the next few years after he moved to Canada in 1989. His trainings in both disciplines made him naturally moving his career into bioinformatics in 1997 by taking a position at GDB (Genome Database), when bioinformatics was emerging as an exciting new scientific discipline. In the last 24 years, through various job posts in Canada, UK and China, his career has led me to become a data scientist specialized in large-scale data infrastructure for data management, analysis, integration, search and visualization.

Lecture Title: Nutrient Regulation of Cellular Physiology by Extensive Crosstalk Between O-GlcNAcylation & Phosphorylation

Gerald Warren Hart, Ph.D. is the DeLamar Professor and Director of Biological Chemistry at Johns Hopkins. He is an Associate Editor of J. Biological Chemistry and of Molecular and Cellular Proteomics and an Editor of BBRC. He founded the journal Glycobiology. Hart’s lab. discovered O-GlcNAcylation, he co-led elucidation of GPI anchor biosynthesis, and his lab documented the importance of protein structure for N-glycosylation. His lab discovered the extensive crosstalk between O-GlcNAc and phosphorylation, which regulates transcription and signaling and underlies the etiology of diabetes, neurodegenerative disease, cardiovascular disease and cancer. ~295 publications; Google H-factor = 102; i10-index=264.

Lecture Title: Modulation of multiple PTMs upon brief cellular stimulation

Lecture Title: Systems-wide analysis of properties and functions of lysine acetylation and ubiquitylation

Dr. Chuna Choudhary is currently a professor and group leader at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen in Denmark. He carried out his doctoral studies at the University of Münster in Germany and his postdoctoral training at the same university as well as at the Max Planck Institute for Biochemistry in Munich, Germany. His laboratory is interested in studying posttranslational modification-based cell signaling networks using quantitative mass spectrometry-based approaches. His group uses quantitative mass spectrometry-based proteomics to investigate the dynamics of lysine acetylation and ubiquitylation in cellular signaling networks. By combining quantitative proteomics with cell and molecular biology approaches the group studies the properties and functions of these modifications. Dr. Choudhary has widely published in high-ranked journals and received several honors and awards, including the EMBO Young Investigator award, the Danish Cancer Society Junior Researcher award, and the ERC Consolidator grant.

Lecture Title: Discovery and initial characterization of a family of lysine acylation pathways

Yingming Zhao received his Ph.D. degree from the Rockefeller University under Professor Brian Chait in 1997. He is currently a Professor in the Ben May Department for Cancer Research at the University of Chicago. His main research interests lie in developing and applying MS-based proteomics technologies to discovery of protein post-translational modification (PTM) pathways. He also use an integrated approach, involving proteomics, biochemistry, molecular biology, and cell biology to decode PTM networks that have implications for human health and are not amenable to conventional techniques. His lab recently discovered eight types of new lysine acylation pathways: propionylation, butyrylation, crotonylation, malonylation, succinylation, glutarylation, and 2-hydroxyisobutyrylation, and 3-hydroxybutyrylation. They identified about 350 new histone marks, which more than doubles the number of previously described histone marks that were discovered over the past few decades. They revealed numerous specific binders and enzymes for the new PTM pathways. Specifically, his lab is the first who demonstrates acetylation-independent functions of deacetylases, including Sirt5 as a desuccinylase and deglutarylase. His laboratory demonstrates that the new PTM pathways have critical roles in epigenetic regulation and cellular metabolism. And these pathways contribute to physiology changes and cellular dysfunctions associated with diverse inborn metabolic diseases, therefore offering new avenues for therapeutic intervention. He is a co-inventor of numerous patents and co-authored 145 peer reviewed papers.

Lecture Title: Analysis Of Tumor Heterogeneity in Three Dimensions by Imaging Mass Cytometry

Bernd Bodenmiller Institute of Molecular Life Sciences, University of Zurich, Switzerland. Bernd Bodenmiller (1979) studied biochemistry at the University of Bayreuth and ETH Zürich and obtained his PhD for his work on sγstem-wide signaling network analysis in the laboratorγ of Ruedi Aebersold at ETH Zürich. For his postdoctoral training, he joined the laboratory of Garry P. Nolan at Sta nford University. There he developed methods for the high throughput analysis of signaling network states by mass cytometry, a technology that allows quantifying up to 100 proteins and signaling molecules at the single celllevel. In 2012, he became group leader and in 2013 SNFjER C assistant professor at the Institute of Molecular Life Sciences at the University of Zürich. Currently his group is developing methods for highly multiplexed imaging by mass cytometry to unravel how trans-cellular signaling network interactions in the tumor microenvironment drive cancer development and ultimatelγmight be exploited for therapeutic targeting.

Lecture Title: The Human Cell Atlas

Emma Lundberg is an Associate Professor of Cell Biology Proteomics at the Royal Institute of Technology in Stockholm, Sweden. The Lundberg lab is located to the Science for Life Laboratory, a newly started national research center for high-throughput molecular bioscience. In the interface between bioimaging and proteomics, her research aims to define the spatiotemporal organization of the human proteome at a subcellular level, and understand how variations and deviations in localization can contribute to cellular function as well as disease. Since 2010 Dr. Lundberg is Director of the Subcellular Atlas, part of the effort of systematically mapping the human proteome using antibodies and the creation of the Human Protein Atlas database (www.proteinatlas.org). For this effort her lab has developed technology platforms for large-scale immunostaining and systematic validation of antibody specificity, as well as initiated citizen science efforts to refine the information in the Human Protein Atlas database. Dr. Lundberg is a member of the Executive Committee of the Human Proteome Organization and the international Human Proteome Project. She received her Ph. D. in Biotechnology in 2008 and holds a M. Sc. in Biotechnological Engineering, both from the Royal Institute of Technology.
Links to social media:
Homepage: www.scilifelab.se/researchers/emma-lundberg/
Database: www.proteinatlas.org
Citizen science project: https://www.eveonline.com/discovery/
LinkedIn: https://se.linkedin.com/in/emma-lundberg-70a87b25